Fitoterapia

Volume 95, June 2014, Pages 115–120

Isocoumarins from American cockroach (Periplaneta americana) and their cytotoxic activities

• Shi-Lin Luo^{a, b, c},
• Xiao-Jun Huang^{b, c},
• Ying Wang^{b, c},
• Ren-Wang Jiang^b,
• Lei Wang^{b, c},
• Liang-Liang Bai^b,
• Qun-Long Peng^b,
• Cai-Lu Song^{b, c},
• Dong-Mei Zhang^{b, ,} ,
• Wen-Cai Ye^{a, b, c, ,}

doi:10.1016/j.fitote.2014.03.004

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Abstract

Four new isocoumarins (1–4), along with three known ones (5–7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana). The structures with absolute configurations of new compounds were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment and CD analyses. Compounds 3–5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC₅₀ values in the ranges 6.41–23.91 μM and 6.67–39.07 μM, respectively.

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Graphical abstract

Keywords

• American cockroach;
• Periplaneta americana;
• Isocoumarin;
• Cytotoxicity

Corresponding author. Tel.: + 86 20 85220936; fax: + 86 20 8522 1559.

Correspondence to: W.-C. Ye, Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Tel.: + 86 20 85220936; fax: + 86 20 8522 1559.

Copyright © 2014 Elsevier B.V. All rights reserved.