Robert Carver, PhD, BASF, Stony Brook, NY, United States; Lisa Mullins,
MS, The Procter and Gamble Company, Cincinnati, OH, United States; Mary
Johnson, MS, The Procter and Gamble Company, Cincinnati, OH, United
States; Rosemarie Osborne, PhD, The Procter and Gamble Company,
Cincinnati, OH, United States
http://dx.doi.org/10.1016/j.jaad.2012.12.135
Background: One approach to enable the renewal of aging skin is
restoration of cellular energy capacity. Niacinamide (NA) increases NADH
levels and provides skin benefits, such as improved barrier, texture,
and uneven pigmentation. In the current work, we evaluated a complex
containing NA, a wrinkle reducing peptide Pal-KTTKS, and an olive
derivative that boosts the antioxidant capacity of skin. The effects of
the complex on ATP, NADH, and procollagen 1 (PC-1) were determined in
human dermal fibroblasts (Fbs) derived from aging adult skin as compared
to young skin.
This work was sponsored 100% by BASF and P&G Beauty
