Reprod Toxicol. 2015 Nov 1;58:234-237. doi: 10.1016/j.reprotox.2015.10.003. [Epub ahead of print]
Hypericum perforatum use during pregnancy and pregnancy outcome.
Abstract
Hypericum perforatum (HP; also known as St. John's Wort) is one of the most commonly used herbal
therapies in the management of depressive illness. The aim of this
study was to evaluate the potential side effects of HP during pregnancy
on pregnancy outcome. Using data from the Danish National Birth Cohort
(DNBC), we investigated outcomes among 38 HP exposed pregnancies
compared to a group of 90,128 women. Associations between HP use and
gestational age, preterm birth, birth weight, malformations and Apgar
scores were investigated. Preterm birth did not differ across the
groups. While the prevalence of malformations in the HP exposed group
was slightly higher (8.1%) than observed in the control groups (3.3%;
p=0.13), this was based on only three cases and was not of any specific
pattern.
Copyright © 2015 Elsevier Inc. All rights reserved.
Copyright © 2015 Elsevier Inc. All rights reserved.
