Biological Activities of the Essential Oil from Erigeron floribundus

Molecules. 2016 Aug 13;21(8). pii: E1065. doi: 10.3390/molecules21081065.

http://www.mdpi.com/1420-3049/21/8/1065

Petrelli R¹, Orsomando G², Sorci L³, Maggi F⁴, Ranjbarian F⁵, Biapa Nya PC⁶, Petrelli D⁷, Vitali LA⁸, Lupidi G⁹, Quassinti L¹⁰, Bramucci M¹¹, Hofer A¹², Cappellacci L¹³.

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Abstract

Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 μmol·TE/g).

KEYWORDS:

Erigeron floribundus; NadD; Trypanosoma brucei; antimicrobial; antioxidant; caryophyllene oxide; cytotoxicity; essential oil; limonene