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Tuesday 10 October 2017

Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals pp 147-174 | Cite as Antidiabetic Medicinal Plants Authors Authors and affiliations Bashar SaadHilal ZaidSiba ShanakSleman Kadan 1. 2. Chapter First Online: 14 May 2017 204 Downloads Abstract Diabetes has been recognized by ancient physicians and its main symptoms were known by the increased thirst, frequent urination, and tiredness. Medicinal plants were commonly used for treating these combined symptoms. In addition to several instructions for specific food consumption, a mild exercise was recommended. Currently, traditional medicine continues to be practiced in most Middle East, Asia, as well as developed countries. The current form of herbal medicine has historical roots in medieval Greco-Arab, ancient Egyptians, Chinese, and other ancient medicines. More than 800 plant species are reported as antidiabetic. Over 400 plants as well as 700 recipes and compounds have been scientifically evaluated for type 2 diabetes treatment. For instance, metformin, the most popular antidiabetic drug nowadays, was developed based on a biguanide compound isolated from French lilac. Medicinal herbs contain various bioactive compounds and thus can display multiple actions on insulin production as well as distinct insulin action mechanisms: insulin sensitizing, insulin mimicking, and inhibition of intestinal carbohydrate digestion and absorption. Herbal-derived insulin sensitizers act in a synergetic mechanism to increase glucose disposal and uptake by muscle, hepatic cells, and fat as well as those that control hepatic glycogen metabolism. This chapter provides a comprehensive overview on traditional herbal medicine including the historical background, medical innovations introduced by physicians and researchers, methods of therapies, and a state-of-the-art description of traditional herbal medicine. References 1. Zaid H, Antonescu CN, Randhawa VK, Klip A (2008) Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J 413:201–215 CrossRefGoogle Scholar 2. Newman DJ (2008) Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem 51:2589–2599 CrossRefGoogle Scholar 3. Zaid H, Rayan J, Nasser A, Saad B, Rayan A (2010) Physicochemical properties of natural based products versus synthetic chemicals. Open Nutra J 3:194–202 Google Scholar 4. Zaid H, Saad B (2013) State of the art of diabetes treatment in Greco-Arab and Islamic medicine. In: Watson RR, Preedy VR (eds) Bioactive food as dietary interventions for diabetes. Academic Press, San Diego/London, pp 327–335 CrossRefGoogle Scholar 5. Kadan S, Saad B, Sasson Y, Zaid H (2016) In vitro evaluation of anti-diabetic activity and cytotoxicity of chemically analysed Ocimum basilicum extracts. Food Chem 196:1066–1074 CrossRefGoogle Scholar 6. Saad B, Said O (2011) Greco-Arab and Islamic herbal medicine: traditional system, ethics, safety, efficacy, and regulatory issues. Wiley, Hoboken CrossRefGoogle Scholar 7. Sheela CG, Augusti KT (1992) Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J Exp Biol 30:523–526 Google Scholar 8. Benhaddou-Andaloussi A, Martineau LC, Vallerand D, Haddad Y, Afshar A et al (2008) Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. Diabetes Obes Metab 12:148–157 CrossRefGoogle Scholar 9. Philips GO, Williams PA (2001) Tree exudates gums: natural and versatile food additives and ingredients. Food Ingred Anal Int 23:26–28 Google Scholar 10. Anderson DMW, Stoddart JF (1966) Studies on uronic acid materials. Carbohydr Res 2:104–114 CrossRefGoogle Scholar 11. Verbeken D, Dierckx S, Dewettinck K (2003) Exudate gums: occurrence, production, and applications. Appl Microbiol Biotechnol 63:10–21 CrossRefGoogle Scholar 12. Patel DK, Prasad SK, Kumar R, Hemalatha S (2012) An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2:320–330 CrossRefGoogle Scholar 13. Singh LW (2011) Traditional medicinal plants of Manipur as anti-diabetics. J Med Plant Res 5:677–687 Google Scholar 14. Singh N, Singh SP, Vrat S, Misra N, Dixit KS et al (1985) A study on the anti-diabetic activity of Coccinia indica in dogs. Indian J Med Sci 39(27–29):42 Google Scholar 15. Zaid H, Rayan A, Said O, Saad B (2010) Cancer treatment by Greco-Arab and Islamic herbal medicine. Open Nutraceuticals J 3:203–212 Google Scholar 16. Sheela CG, Kumud K, Augusti KT (1995) Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 61:356–357 CrossRefGoogle Scholar 17. Grover JK, Yadav S, Vats V (2002) Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 81:81–100 CrossRefGoogle Scholar 18. Mustafa SSS, Eid NI, Jafri SA, El-Latif HAA, Ahmed HMS (2007) Insulinotropic effect of aqueous ginger extract and aqueous garlic extract on the isolated perfused pancreas of streptozotocin induced diabetic rats. Pak J Zool 39:279–284 Google Scholar 19. Ayodhya S, Kusum S, Anjali S (2010) Hypoglycaemic activity of different extracts of various herbal plants Singh. Int J Ayurveda Res Pharm 1:212–224 Google Scholar 20. Chauhan A, Sharma PK, Srivastava P, Kumar N, Duehe R (2010) Plants having potential antidiabetic activity: a review. Der Pharm Lett 2:369–387 Google Scholar 21. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP (2007) Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 40:163–173 CrossRefGoogle Scholar 22. Singh V, Singh SP, Singh M, Gupta AK, Kumar A (2015) Combined potentiating action of phytochemical(s) from Cinnamomum tamala and Aloe vera for their anti-diabetic and insulinomimetic effect using in vivo rat and in vitro NIH/3 T3 cell culture system. Appl Biochem Biotechnol 175:2542–2563 CrossRefGoogle Scholar 23. Taukoorah U, Mahomoodally MF (2016) Crude Aloe vera gel shows antioxidant propensities and inhibits pancreatic lipase and glucose movement in vitro. Adv Pharmacol Sci 2016:3720850 Google Scholar 24. Zhang Y, Liu W, Liu D, Zhao T, Tian H (2016) Efficacy of Aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Nutrients 8(7). pii: E388 Google Scholar 25. Ravikumar R, Krishnamoorthy P, Kalidoss A (2010) Antidiabetic and antioxidant efficacy of Andrographis paniculata in alloxanized albino rats. Int J Pharm Technol 2:1016–1027 Google Scholar 26. Akbar S (2011) Andrographis paniculata: a review of pharmacological activities and clinical effects. Altern Med Rev 16:66–77 Google Scholar 27. Adler JH, Lazarovici G, Marton M, Levy E (1986) The diabetic response of weanling sand rats (Psammomys obesus) to diets containing different concentrations of salt bush (Atriplex halimus). Diabetes Res 3:169–171 Google Scholar 28. Aharonson Z, Shani J, Sulman FG (1969) Hypoglycaemic effect of the salt bush (Atriplex halimus)–a feeding source of the sand rat (Psammomys obesus). Diabetologia 5:379–383 CrossRefGoogle Scholar 29. Said O, Fulder S, Khalil K, Azaizeh H, Kassis E et al (2008) Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional Arab herbal medicine. Evid Based Complement Alternat Med 5:421–428 CrossRefGoogle Scholar 30. Patil KS, Bhalsing SR (2015) Efficient micropropagation and assessment of genetic fidelity of Boerhaavia diffusa L- high trade medicinal plant. Physiol Mol Biol Plants 21:425–432 CrossRefGoogle Scholar 31. Murti K, Panchal MA, Lambole V (2010) Pharmacological properties of Boerhaavia diffusa – a review. Int J Pharm Sci Rev Res 5:107–110 Google Scholar 32. Roy PK (2008) Rapid multiplication of Boerhaavia diffusa L through in vitro culture of shoot tip and nodal explants. Plant Tiss Cult Biotech 18:49–56 Google Scholar 33. Chaudhary G, Dantu PK (2011) Morphological, phytochemical and pharmacological studies on Boerhaavia diffusa L. J Med Plants Res 5:2125–2130 Google Scholar 34. Singh PK, Baxi D, Doshi A, Ramachandran AV (2011) Antihyperglycaemic and renoprotective effect of Boerhaavia diffusa L. in experimental diabetic rats. J Complement Integr Med 8(1):1533 Google Scholar 35. Malviya N, Jain S, Malviya S (2010) Antidiabetic potential of medicinal plants. Acta Pol Pharm 67:113–118 Google Scholar 36. Gramza-Michalowska A, Kobus-Cisowska J, Kmiecik D, Korczak J, Helak B et al (2016) Antioxidative potential, nutritional value and sensory profiles of confectionery fortified with green and yellow tea leaves (Camellia sinensis). Food Chem 211:448–454 CrossRefGoogle Scholar 37. Islam MS, Choi H (2007) Green tea, anti-diabetic or diabetogenic: a dose response study. Biofactors 29:45–53 CrossRefGoogle Scholar 38. Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X et al (2014) Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARgamma): a review. Biochem Pharmacol 92:73–89 CrossRefGoogle Scholar 39. Ferreira MA, Silva DM, de Morais AC Jr, Mota JF, Botelho PB (2016) Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults – a review. Obes Rev 17(12):1316–1328 CrossRefGoogle Scholar 40. Lasaite L, Spadiene A, Savickiene N, Skesters A, Silova A (2014) The effect of Ginkgo biloba and Camellia sinensis extracts on psychological state and glycemic control in patients with type 2 diabetes mellitus. Nat Prod Commun 9:1345–1350 Google Scholar 41. Nabeel MA, Kathiresan K, Manivannan S (2010) Antidiabetic activity of the mangrove species Ceriops Decandra in alloxan-induced diabetic rats. J Diabetes 2:97–103 CrossRefGoogle Scholar 42. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA (2003) Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 26:3215–3218 CrossRefGoogle Scholar 43. Mancini-Filho J, Van-Koiij A, Mancini DA, Cozzolino FF, Torres RP (1998) Antioxidant activity of cinnamon (Cinnamomum zeylanicum, Breyne) extracts. Boll Chim Farm 137:443–447 Google Scholar 44. Shalaby MA, Saifan HY (2014) Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats. J Intercult Ethnopharmacol 3:144–149 CrossRefGoogle Scholar 45. Shafaei H, Rad JS, Delazar A, Behjati M (2014) The effect of pulp and seed extract of Citrullus colocynthis, as an antidiabetic medicinal herb, on hepatocytes glycogen stores in diabetic rabbits. Adv Biomed Res 3:258 CrossRefGoogle Scholar 46. Shi C, Karim S, Wang C, Zhao M, Murtaza G (2014) A review on antidiabetic activity of Citrullus colocynthis Schrad. Acta Pol Pharm 71:363–367 Google Scholar 47. Barghamdi B, Ghorat F, Asadollahi K, Sayehmiri K, Peyghambari R et al (2016) Therapeutic effects of Citrullus colocynthis fruit in patients with type II diabetes: a clinical trial study. J Pharm Bioallied Sci 8:130–134 CrossRefGoogle Scholar 48. Li Y, Zheng M, Zhai X, Huang Y, Khalid A et al (2015) Effect of-Gymnema sylvestre, Citrullus colocynthis and Artemisia absinthium on blood glucose and lipid profile in diabetic human. Acta Pol Pharm 72:981–985 Google Scholar 49. Dallak MA, Bin-Jaliah I, Al-Khateeb MA, Nwoye LO, Shatoor AS et al (2010) In vivo acute effects of orally administered hydro-ethanol extract of Catha edulis on blood glucose levels in normal, glucose-fed hyperglycemic, and alloxan-induced diabetic rats. Saudi Med J 31:627–633 Google Scholar 50. Dallak M, Bashir N, Abbas M, Elessa R, Haidara M et al (2009) Concomitant down regulation of glycolytic enzymes, upregulation of gluconeogenic enzymes and potential hepato-nephro-protective effects following the chronic administration of the hypoglycemic, insulinotropic Citrullus colocynthis pulp extract. Am J Biochem Biotechnol 5:153–161 CrossRefGoogle Scholar 51. Joo SJ, Park JH, Seo BI (2007) Effects of Korean Corni fructus on treatment of osteoporosis in ovariectomized rats. The Korea J Herbology 22:83–95 Google Scholar 52. Kim DK, Kwak JH (1998) A furan derivative from Cornus officinalis. Arch Pharm Res 21:787–789 CrossRefGoogle Scholar 53. Lee NH, Seo CS, Lee HY, Jung DY, Lee JK et al (2012) Hepatoprotective and antioxidative activities of Cornus officinalis against acetaminophen-induced hepatotoxicity in mice. Evid Based Complement Alternat Med 2012:804924 Google Scholar 54. Akhavan N, Feresin R, Johnson S, Pourafshar S, Elam M et al (2015) Cornus officinalis Modulates the production of pro-inflammatory molecules in lipopolysaccharide-activated RAW264.7 macrophages. FASEB J 29:922–930 Google Scholar 55. Hwang KA, Hwang YJ, Song J (2016) Antioxidant activities and oxidative stress inhibitory effects of ethanol extracts from Cornus officinalis on raw 264.7 cells. BMC Complement Altern Med 16:196 CrossRefGoogle Scholar 56. Chen CC, Hsu CY, Chen CY, Liu HK (2008) Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. J Ethnopharmacol 117:483–490 CrossRefGoogle Scholar 57. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A (2006) Medicinal plants with potential antidiabetic activity-a review of ten years of herbal medicine research (1990–2000). Int J Diabetes Metab 14:1–25 Google Scholar 58. De B, Bhandari K, Singla RK, Katakam P, Samanta T et al (2015) Chemometrics optimized extraction procedures, phytosynergistic blending and in vitro screening of natural enzyme inhibitors amongst leaves of Tulsi, banyan and Jamun. Pharmacogn Mag 11:S522–S532 CrossRefGoogle Scholar 59. Bailey CJ, Campbell IW, Chan JCN, Davidson JA, HCS H et al (2007) Metformin: the gold standard. A scientific handbook. Wiley, Chichester. Chapter 1 Google Scholar 60. Witters LA (2001) The blooming of the French lilac. J Clin Invest 108:1105–1107 CrossRefGoogle Scholar 61. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR et al (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of diabetes. Diabetes Care 32:193–203 CrossRefGoogle Scholar 62. Salpeter S, Greyber E, Pasternak G, Salpeter E (2006) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev (4): CD002967 Google Scholar 63. Kim HJ, Hong SH, Chang SH, Kim S, Lee AY et al (2016) Effects of feeding a diet containing Gymnema sylvestre extract: attenuating progression of obesity in C57BL/6 J mice. Asian Pac J Trop Med 9:437–444 CrossRefGoogle Scholar 64. Tiwari P, Mishra BN, Sangwan NS (2014) Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int 2014:830285 Google Scholar 65. Rao MU, Sreenivasulu M, Chengaiah B, Reddy KJ, Chetty CM (2010) Herbal medicines for diabetes mellitus: a review. Int J PharmTech Res 2:1883–1892 Google Scholar 66. Saxena A, Vikram NK (2004) Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 10:369–378 CrossRefGoogle Scholar 67. Kaczmar T (1998) Herbal support for diabetes management. Clin Nutr Insights 6:1–4 Google Scholar 68. Kumar PM, Venkataranganna MV, Manjunath K, Viswanatha GL, Ashok G (2016) Methanolic leaf extract of Gymnema sylvestre augments glucose uptake and ameliorates insulin resistance by upregulating glucose transporter-4, peroxisome proliferator-activated receptor-gamma, adiponectin, and leptin levels in vitro. J Intercult Ethnopharmacol 5:146–152 CrossRefGoogle Scholar 69. Erdemoglu N, Kupeli E, Yesilada E (2003) Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J Ethnopharmacol 89:123–129 CrossRefGoogle Scholar 70. Cruz-Vega DE, Verde-Star MJ, Salinas-Gonzalez N, Rosales-Hernandez B, Estrada-Garcia I et al (2008) Antimycobacterial activity of Juglans regia, Juglans Mollis, Carya Illinoensis and Bocconia frutescens. Phytother Res 22:557–559 CrossRefGoogle Scholar 71. Saad B, Azaizeh H, Said O (2008) Arab herbal medicine. Bot Med Clin Pract 4:31–39 Google Scholar 72. Tieppo J, Vercelino R, Dias AS, Silva Vaz MF, Silveira TR et al (2007) Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food Chem Toxicol 45:1140–1146 CrossRefGoogle Scholar 73. Pereiraa JA, Oliveiraa I, Sousaa A, Valentãob R, Andradeb PB et al (2007) Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol 45:2287–2295 CrossRefGoogle Scholar 74. Fukuda T, Ito H, Yoshida T (2004) Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. Biofactors 21:251–253 CrossRefGoogle Scholar 75. Grover JK, Yadav SP (2004) Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol 93:123–132 CrossRefGoogle Scholar 76. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P et al (2015) Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids 2015:496169 CrossRefGoogle Scholar 77. Raman A, Lau C (1996) Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 2:349–362 CrossRefGoogle Scholar 78. Chen ZH (2014) Advance on hypoglycemic function of bitter gourd components. J Food Ind 35:250–252 Google Scholar 79. Sun FQ, Zhang G, Huang B, Bai J, Yu X (2000) Clinical observation of using bitter melon to treat DM. Liaoning J Pract Diabetol 8:34–35 Google Scholar 80. Chen H, Guo J, Pang B, Zhao L, Tong X (2015) Application of herbal medicines with bitter flavor and cold property on treating diabetes mellitus. Evid Based Complement Alternat Med 2015:529491 Google Scholar 81. Ahmed I, Adeghate E, Cummings E, Sharma AK, Singh J (2004) Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem 261:63–70 CrossRefGoogle Scholar 82. Miura T, Itoh C, Iwamoto N, Kato M, Kawai M et al (2001) Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. J Nutr Sci Vitaminol (Tokyo) 47:340–344 CrossRefGoogle Scholar 83. Shih CC, Lin CH, Lin WL, Wu JB (2009) Momordica charantia Extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J Ethnopharmacol 123:82–90 CrossRefGoogle Scholar 84. Roffey BW, Atwal AS, Johns T, Kubow S (2007) Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3 T3-L1 adipose cells. J Ethnopharmacol 112:77–84 CrossRefGoogle Scholar 85. Cummings E, Hundal HS, Wackerhage H, Hope M, Belle M et al (2004) Momordica charantia Fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Mol Cell Biochem 261:99–104 CrossRefGoogle Scholar 86. Kumar R, Balaji S, Uma TS, Sehgal PK (2009) Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate glut-4, PPAR gamma and PI3K. J Ethnopharmacol 126:533–537 CrossRefGoogle Scholar 87. Ahmed I, Adeghate E, Sharma AK, Pallot DJ, Singh J (1998) Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Res Clin Pract 40:145–151 CrossRefGoogle Scholar 88. Sathishsekar D, Subramanian S (2005) Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull 28:978–983 CrossRefGoogle Scholar 89. Yibchok-anun S, Adisakwattana S, Yao CY, Sangvanich P, Roengsumran S et al (2006) Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol Pharm Bull 29:1126–1131 CrossRefGoogle Scholar 90. Chen Q, Chan LL, Li ET (2003) Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr 133:1088–1093 Google Scholar 91. Sridhar MG, Vinayagamoorthi R, Arul Suyambunathan V, Bobby Z, Selvaraj N (2008) Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr 99:806–812 CrossRefGoogle Scholar 92. Lo HY, Ho TY, Lin C, Li CC, Hsiang CY (2013) Momordica charantia And its novel polypeptide regulate glucose homeostasis in mice via binding to insulin receptor. J Agric Food Chem 61:2461–2468 CrossRefGoogle Scholar 93. Salem ML (2005) Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 5:1749–1770 CrossRefGoogle Scholar 94. Agarwal R, Kharya MD, Shrivastava R (1979) Antimicrobial & anthelmintic activities of the essential oil of Nigella sativa Linn. Indian J Exp Biol 17:1264–1265 Google Scholar 95. Gilani AH, Jabeen Q, Khan M (2004) A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci 7:441–451 CrossRefGoogle Scholar 96. Katzer G Spice Pages: Basil (Ocimum basilicum/sanctum/tenuiflorum/canum). gernot-katzers-spice-pagescom Google Scholar 97. El-Soud NH, Deabes M, El-Kassem LA, Khalil M (2015) Chemical composition and antifungal activity of Ocimum basilicum L. essential oil. Open Access Maced J Med Sci 3:374–379 CrossRefGoogle Scholar 98. El-Beshbishy H, Bahashwan S (2012) Hypoglycemic effect of basil (Ocimum basilicum) aqueous extract is mediated through inhibition of alpha-glucosidase and alpha-amylase activities: an in vitro study. Toxicol Ind Health 28:42–50 CrossRefGoogle Scholar 99. Zeggwagh NA, Sulpice T, Eddouks M (2007) Anti-hyperglycaemic and hypolipidemic effects of Ocimum basilicum aqueous extract in diabetic rats. Am J Pharmacol Toxicol 2:123–129 CrossRefGoogle Scholar 100. Govindarajan M, Sivakumar R, Rajeswary M, Yogalakshmi K (2013) Chemical composition and larvicidal activity of essential oil from Ocimum basilicum (L.) against Culex tritaeniorhynchus, Aedes albopictus and Anopheles Subpictus (Diptera: Culicidae). Exp Parasitol 134:7–11 CrossRefGoogle Scholar 101. de Almeida LF, Frei F, Mancini E, De Martino L, De Feo V (2010) Phytotoxic activities of Mediterranean essential oils. Molecules 15:4309–4323 CrossRefGoogle Scholar 102. Zhang JW, Li SK, Wu WJ (2009) The main chemical composition and in vitro antifungal activity of the essential oils of Ocimum basilicum Linn. Var. Pilosum (Willd.) Benth Molecules 14:273–278 CrossRefGoogle Scholar 103. Bayala B, Bassole IH, Gnoula C, Nebie R, Yonli A et al (2014) Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso. PLoS One 9:e92122 CrossRefGoogle Scholar 104. El SN, Karakaya S (2009) Olive tree (Olea europaea) leaves: potential beneficial effects on human health. Nutr Rev 67:632–638 CrossRefGoogle Scholar 105. Benavente-Garcia O, Castillo J, Lorente J, Alcaraz M (2002) Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds. J Med Food 5:125–135 CrossRefGoogle Scholar 106. Karunamoorthi K, Mulelam A, Wassie F (2008) Laboratory evaluation of traditional insect/mosquito repellent plants against anopheles arabiensis, the predominant malaria vector in Ethiopia. Parasitol Res 103:529–534 CrossRefGoogle Scholar 107. Fu S, Arraez-Roman D, Segura-Carretero A, Menendez JA, Menendez-Gutierrez MP et al (2010) Qualitative screening of phenolic compounds in olive leaf extracts by hyphenated liquid chromatography and preliminary evaluation of cytotoxic activity against human breast cancer cells. Anal Bioanal Chem 397:643–654 CrossRefGoogle Scholar 108. Paiva-Martins F, Pinto M (2008) Isolation and characterization of a new hydroxytyrosol derivative from olive (Olea europaea) leaves. J Agric Food Chem 56:5582–5588 CrossRefGoogle Scholar 109. Lee OH, Lee BY, Lee J, Lee HB, Son JY et al (2009) Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. Bioresour Technol 100:6107–6113 CrossRefGoogle Scholar 110. Sudjana AN, D'Orazio C, Ryan V, Rasool N, Ng J et al (2009) Antimicrobial activity of commercial Olea europaea (olive) leaf extract. Int J Antimicrob Agents 33:461–463 CrossRefGoogle Scholar 111. Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN et al (2002) Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats. Arzneimittelforschung 52:797–802 Google Scholar 112. Saijaa A, Trombettaa D, Tomainoa A, Lo Cascioa R, Princib P et al (1998) In vitro evaluation of the antioxidant activity and biomembrane interaction of the plant phenols oleuropein and hydroxytyrosol. Int J Pharm 166:123–133 CrossRefGoogle Scholar 113. Bahramikia S, Yazdanparast R (2012) Phytochemistry and medicinal properties of Teucrium Polium L. (Lamiaceae). Phytother Res 26:1581–1593 CrossRefGoogle Scholar 114. Esmaeili MA, Yazdanparast R (2004) Hypoglycaemic effect of Teucrium Polium: studies with rat pancreatic islets. J Ethnopharmacol 95:27–30 CrossRefGoogle Scholar 115. Gharaibeh MN, Elayan HH, Salhab AS (1988) Hypoglycemic effects of Teucrium Polium. J Ethnopharmacol 24:93–99 CrossRefGoogle Scholar 116. Shahraki MR, Arab MR, Mirimokaddam E, Palan MJ (2007) The effect of Teucrium Polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats. Iran Biomed J 11:65–68 Google Scholar 117. Mohseni Salehi Monfared SS, Pournourmohammadi S (2010) Teucrium Polium Complex with molybdate enhance cultured islets secretory function. Biol Trace Elem Res 133:236–241 CrossRefGoogle Scholar 118. Mousavi SE, Shahriari A, Ahangarpour A, Vatanpour H, Jolodar A (2012) Effects of Teucrium Polium ethyl acetate extract on serum, liver and muscle triglyceride content of sucrose-induced insulin resistance in rat. Iran J Pharm Res 11:347–355 Google Scholar 119. Mousavi SM, Niazmand S, Hosseini M, Hassanzadeh Z, Sadeghnia HR et al (2015) Beneficial effects of Teucrium Polium and metformin on diabetes-induced memory impairments and brain tissue oxidative damage in rats. Int J Alzheimers Dis 2015:493729 Google Scholar 120. Hamden K, Masmoudi H, Carreau S, Elfeki A (2010) Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Immunopharmacol Immunotoxicol 32:437–445 CrossRefGoogle Scholar 121. Ramadan G, El-Beih NM, Abd El-Kareem HF (2010) Anti-metabolic syndrome and immunostimulant activities of Egyptian fenugreek seeds in diabetic/obese and immunosuppressive rat models. Br J Nutr 105(7):995–1004 CrossRefGoogle Scholar 122. Sharma RD, Raghuram TC (1990) Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetics subjects. Nutr Res 10:731–739 CrossRefGoogle Scholar 123. Moorthy R, Prabhu KM, Murthy PS (2010) Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. Indian J Exp Biol 48:1111–1118 Google Scholar 124. Legssyer A, Ziyyat A, Mekhfi H, Bnouham M, Tahri A et al (2002) Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta. Phytother Res 16:503–507 CrossRefGoogle Scholar 125. Exarchou V, Fiamegos YC, van Beek TA, Nanos C, Vervoort J (2006) Hyphenated chromatographic techniques for the rapid screening and identification of antioxidants in methanolic extracts of pharmaceutically used plants. J Chromatogr A 1112:293–302 CrossRefGoogle Scholar 126. Nassiri-Asl M, Zamansoltani F, Abbasi E, Daneshi MM, Zangivand AA (2009) Effects of Urtica dioica extract on lipid profile in hypercholesterolemic rats. Zhong Xi Yi Jie He Xue Bao 7:428–433 CrossRefGoogle Scholar 127. Tarhan O, Alacacioglu A, Somali I, Sipahi H, Zencir M et al (2009) Complementary-alternative medicine among cancer patients in the western region of Turkey. J BUON 14:265–269 Google Scholar 128. Anderson BE, Miller CJ, Adams DR (2003) Stinging nettle dermatitis. Am J Contact Dermat 14:44–46 CrossRefGoogle Scholar 129. Zohary M (1982) Plants of the bible. Cambridge University Press, Cambridge, pp 154–155 Google Scholar 130. Mandavillae JP (1990) Flora of eastern Sausi Arabia. Kegan Paul International, London Google Scholar 131. Farooqi A (1977) Plants of the Qur'an. Sidrah Publishers, Lucknow, pp 65–74 Google Scholar 132. Grace CM, Baldenserger L (1932) From cedar to hyssop. A study in the folklore of plants in Palestine. The Sheldon Press, London, pp 112–113 Google Scholar 133. Waggas AM, Al-Hasani RH (2010) Neurophysiological study on possible protective and therapeutic effects of Sidr (Zizyphus spina-christi L.) leaf extract in male albino rats treated with pentylenetetrazol. Saudi J Biol Sci 17:269–274 CrossRefGoogle Scholar 134. Abdel-Zaher AO, Salim SY, Assaf MH, Abdel-Hady RH (2005) Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol 101:129–138 CrossRefGoogle Scholar 135. Nyenwea EA, Jerkinsb TW, Umpierrezc GE, Kitabchi AE (2011) Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism 60(1):1–23 CrossRefGoogle Scholar 136. Piya MK, Tahrani AA, Barnett AH (2010) Emerging treatment options for type 2 diabetes. Br J Clin Pharmacol 70(5):631–644 CrossRefGoogle Scholar 137. Sangeetha MK, Mohana Priya CD, Vasanthi HR (2013) Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of glut-4 in L6 myotubes. Phytomedicine 20:246–248 CrossRefGoogle Scholar 138. Modi P (2007) Diabetes beyond insulin: review of new drugs for treatment of diabetes mellitus. Curr Drug Discov Technol 4:39–47 CrossRefGoogle Scholar 139. Neustadt J, Pieczenik SR (2008) Medication-induced mitochondrial damage and disease. Mol Nutr Food Res 52:780–788 CrossRefGoogle Scholar 140. Butler MS (2004) The role of natural product chemistry in drug discovery. J Nat Prod 67:2141–2153 CrossRefGoogle Scholar 141. Fabricant DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109(Suppl 1):69–75 CrossRefGoogle Scholar 142. Corcoran O, Spraul M (2003) LC-NMR-MS in drug discovery. Drug Discov Today 8:624–631 CrossRefGoogle Scholar 143. Rayan A, Noy E, Chema D, Levitzki A, Goldblum A (2004) Stochastic algorithm for kinase homology model construction. Curr Med Chem 11:675–692 CrossRefGoogle Scholar 144. Steinbeck C (2004) Recent developments in automated structure elucidation of natural products. Nat Prod Rep 21:512–518 CrossRefGoogle Scholar 145. Harvey AL (2008) Natural products in drug discovery. Drug Discov Today 13:894–901 CrossRefGoogle Scholar 146. Saad B, Azaizeh H, Said O (2005) Tradition and perspectives of Arab herbal medicine: a review. Evid Based Complement Alternat Med 2:475–479 CrossRefGoogle Scholar Copyright information © Springer International Publishing AG 2017